Our aim is to promote safe, compassionate, ethical and evidence-informed healthcare for children, adolescents, and young adults with gender dysphoria
Historically, the small numbers of children presenting with gender dysphoria were primarily prepubescent males. In recent years, there has been a sharp increase in referrals of adolescents, and particularly adolescent females, to gender clinics. Many do not have a significant history of childhood gender dysphoria and a number suffer from comorbid mental health issues and neurodevelopmental conditions such as autism (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD). The reasons for these changes are understudied and remain poorly understood.
Childhood-onset gender dysphoria has been shown to have a high rate of natural resolution, with 61-98% of children reidentifying with their biological sex during puberty. The research into the course of gender dysphoria desistance among the cohort presenting with adolescent-onset gender dysphoria is still in its infancy, due to the novelty of this presentation. However, recent research from the UK clinic population suggests that 10-12% of youth may be detransitioning within 16 months to 5 years of initiating medical interventions, with an additional 20-22% discontinuing treatments for a range of reasons. The researchers noted that the detransition rate found in the recently-presenting population raises critical questions about the phenomenon of "overdiagnosis, overtreatment, or iatrogenic harm as found in other medical fields." U.S. data suggest that the rate of medical detransition has reached ~30%.
For two years in a row, AAP members submitted formal resolutions to the executive board asking “that the academy commit to the principles of evidence based medicine by eschewing narrative and other types of non-systematic reviews as the basis for its recommendations” and either use existing systematic reviews or commission its own.
A resolution submitted in April with two dozen signatories also asked that an “urgent statement” be made urging paediatricians “to exercise extreme caution in transitioning minors with hormones and surgeries pending the results.”
The lead author of these resolutions, Julia Mason, a paediatrician in Gresham, Oregon, and a founder of the Society for Evidence-Based Gender Medicine, told The BMJ she is “gratified” that AAP is “making a commitment to look at the evidence” but is “disappointed they are not taking a precautionary approach.”
AAP announced that its policy update process will be “transparent and inclusive,” and will “invite members and other stakeholders to share input.”
Mason said, “I’m hoping that means that they will include clinicians with different views, detransitioners, and parents.”
In June, England’s National Health Service announced that it would restrict the use of puberty blockers to clinical trials because “there is not enough evidence to support their safety or clinical effectiveness as a routinely available treatment.” Last year, Sweden’s national health care oversight body similarly determined that, on the basis of its systematic review, “the risks of puberty-inhibiting and gender-affirming hormone treatment for those under 18 currently outweigh the possible benefits.”
In the United States, a small group of pediatricians has pushed for a similar review from the A.A.P., one of the few institutions with enough centralized power to influence health care practices. Dr. Julia Mason, a pediatrician in Gresham, Ore., co-founded a group called the Society for Evidence-Based Gender Medicine that has been highly critical of gender treatments for minors. Since 2020, she said, she has unsuccessfully lobbied the academy’s leadership to commission a systematic review. Dr. Mason said she was pleased the group finally decided to take a close look at the data. “We are making strong recommendations based on weak evidence,” she said.
The Dutch team’s approach was deliberately conservative. Patients had to have suffered from gender dysphoria since before puberty. Many of today’s patients say they began to suffer from dysphoria as teenagers. The Dutch protocol excludes those with mental- health problems from receiving treatment. But 70% or more of the young people seeking treatment suffer from mental-health problems, according to three recent papers looking at patients in America, Australia and Finland.
Despite the protocol’s caution, says Will Malone of the Society for Evidence-Based Gender Medicine, an international group of concerned clinicians, the reality is often the reverse, especially in America, with mental-health issues becoming a reason to proceed with transitions, rather than to stop them.
I spoke to Dr. William Malone, an endocrinologist and a board member of the Society for Evidence-based Gender Medicine about the use of puberty blockers in young people. He says we don’t know enough about their long-term effects. “A child on blockers is halted in physical and likely emotional maturity,” he said. “Within a year or two, their peers will be profoundly different, and they become out of sync. Puberty is not just a physical event, it’s a psychosocial event with your peers. There is brain development that occurs. Blocking puberty likely has important implications for functionality as an adult.”
Even leaders of the Society for Evidence-based Gender Medicine, who are wholly skeptical of the acceleration in gender-affirming care, said ‘it is not accurate to say that the Biden administration is pushing these interventions on kids.’ ‘Presumably, children don’t read the statements by the administration endorsing gender-affirming care,” a society spokesperson said. "We find the politicization of transgender health deeply problematic and unhelpful. Unfortunately, much of the U.S. has taken a politicized approach, on both sides of the debate.’”
Five AAP members, which has a total membership of around 67,000 pediatricians in the United States and Canada, this year penned Resolution 27, calling for a possible update of the guidelines following consultation with stakeholders that include mental health and medical clinicians, parents, and patients "with diverse views and experiences." ... This year, the AAP sent an email to members stating it would not allow comments on resolutions that had not been "sponsored" by one of the group's 66 chapters or 88 internal committees, councils, or sections. ... Julia Mason, MD, a board member for the Society for Evidence-based Gender Medicine (SEGM) and a pediatrician in private practice in Gresham, Oregon, says an AAP chapter president agreed to second Resolution 27 but backed off after attending a different AAP meeting. Mason did not name the member.
“William Malone, an endocrinologist with the Society for Evidence-based Gender Medicine, a non-profit group, sees parallels with previous medical scandals, not least the opioid crisis. There is a mix of “Big Pharma, a vulnerable patient population, and physicians misled by medical organisations or tempted by wealth and prestige”, he says. But now there is gender-identity ideology on top. “We are completely saturated with corporate influences and lobby groups,” says Dr Malone. “The only way they will be halted is if a massive number of people are harmed and they get together to sue the people who harmed them.””
“Likewise, the Society for Evidence Based Gender Medicine (SEGM) fact-checked HHS' document. SEGM found the guidance contains "a number of errors and misrepresentations" and "many highly inaccurate" claims. It raised concerns over the manner the guidance was developed, noting its inadequate literature review, biased recommendations that do not acknowledge the low quality of evidence it relies upon, failure to consult a range of views—such as those for whom "gender-affirming" care was not beneficial—and failure to identify or acknowledge alternative treatments.”
The Society for Evidence-Based Gender Medicine, a nonprofit group of health professionals who are concerned about medical transition risks for minors, said other evidence shows high numbers of kids outgrow transgender identities by puberty or adulthood. Dr. William Malone, an advisor to the group, said the new study appears to reinforce concerns “that early social gender transition may cement a young person’s transgender identity, and lead minors on the path to eventual medicalization, with all its inherent risks and uncertainties.’’
In an email to Undark, SEGM cited research stating that the proportion of gender dysphoric youth who later desist could be much higher than other estimates suggest. “The key issue,” the group wrote, “is that there is no test to determine which youth will persist and which will desist.” ...“SEGM is focused exclusively on the evidence base for treating gender-dysphoric youth (children, adolescents, and young adults),” they wrote. ...The group additionally noted that it has “issued statements of concern regarding laws that attempt to curb or ban exploratory therapy of gender-related distress for youth.”
However, in a commentary recently published in Child and Adolescent Mental Health, Alison Clayton, MBBS, from the University of Melbourne, Australia, and coauthors from the Society for Evidence Based Medicine (SEGM), again point out that evidence reviews of the use of puberty blockers in young people with gender dysphoria show "there is very low certainty of the benefits of puberty blockers, an unknown risk of harm, and there is need for more rigorous research." "The clinically prudent thing to do, if we aim to 'first, do no harm,' is to proceed with extreme caution, especially given the rapidly rising case numbers and novel gender dysphoria presentations," Clayton and colleagues conclude.
"We need a serious organization to take a sober look at the evidence and that is why we have established the Society for Evidence-Based Gender Medicine [SEGM]," she noted. "This is what we do — we are looking at all of the evidence." Mason is a clinical advisor to SEGM, an organization set-up to evaluate current interventions and evidence on gender dysphoria.
Historically, medical interventions to achieve the appearance of the desired sex were reserved primarily for adults with long histories of dysphoria. Such interventions were preceded by a prolonged engagement with the patient, including thorough psychological assessments. While objective population-level data of adult gender transitioners show persistent mental health struggles and sharply elevated mortality and morbidity, subjective patient-reported outcomes suggest low regret rates. Unfortunately, "regret" studies routinely fail to get in touch with 20-60% of the transitioned patients, leaving unanswered questions about the substantial number lost to follow-up. However, there is little reason to doubt that a number of adult transitioners, having made an informed decision regarding the balance of benefits, harms, and uncertainties, live rewarding lives as transgender individuals.
However, around 2010's, there was a marked change in the approach to the management of gender dysphoria, particularly for gender-dysphoric youth. A number of countries in Western Europe, North America, and Australia, began to promote the "gender-affirmative" model of care for youth. Under this model of care, young people presenting with gender dysphoria or asserting a transgender identity are affirmed in their desire to undergo gender transition, and are provided with "barrier-free" hormonal and surgical interventions. While mental health professionals are often involved, their role is typically limited to preparing the young person for gender transition, regardless of any co-occurring mental health challenges or whether there was a relatively recent history of transgender identification. As such, the provision of medical intervention now happens with a much-reduced psychological assessment.
In the last 36 months, a growing number of Western countries have recognized the significant concerns with the "gender-affirmative" model of care, which became visible, in part, due to the growing voices of detransitioners and regretters coming from the novel population of gender-dysphoric youth. After completing systematic reviews of evidence which showed that the risk-benefit ratio of youth transitions ranges from uncertain to unfavorable, these countries have begun to sunset "gender-affirmation." As of the current writing, the following countries have made sharp reversals of their previous "gender affirmation" practices or have signaled an intention to do so in the near future:
In the meantime, in North America:
The practice of medically transitioning minors, currently referred to as "gender-affirmative care," began to gain momentum following a single-site study in the Netherlands. Previously, gender transition was available only to mature adults, with the average age of transition frequently in the 30's. However, it was noted that the results of adult transitions were frequently disappointing, which was believed to be explained by unsatisfactory cosmetic outcomes, particularly for males, who had a "never disappearing masculine appearance." in the 1990's, the Dutch clinicians began to experiment with transitioning minors using endocrine interventions with the hope that a better cosmetic outcome would also lead to better mental health ones. The results of the innovative Dutch experiment, which has become known as "the Dutch Protocol," were documented in two publications: the 2011 study, which reported on cases who underwent puberty blockade, and the 2014 study, which reported on a subset of the cases who completed surgeries, including the removal of ovaries and testes upon reaching the age of 18.
The youth in the Dutch study reported high levels psychological functioning at 1.5 years after surgery, the study end point. However, both of the studies suffer from a high risk of bias due to their study design and suffer from limited applicability to the populations of adolescents presenting today According to a recently-published overview of the Dutch protocol, the interventions described in the study are currently being applied in the way there were not intended. Specifically, adolescents who were not cross-gender identified prior to puberty, who have significant mental health problems, as well as those who have non-binary identities are now commonly treated using endocrine and surgical interventions described by the Dutch—yet all of these presentations were explicitly disqualified from the Dutch protocol.
The study itself suffers from significant limitations, ranging from a weak study design, only marginal improvements in psychological function, and number of under-reported adverse health events that occurred over the course of they study (including 1 case of death and 3 cases of severe morbidity). Researchers have also questions the validity of the gender dysphoria resolution reported by the Dutch, in light of their unusual handling of the gender dysphoria scale. Despite these limitations, the Dutch clinical experiment has become the basis for the practice of medical transition of minors worldwide and serves as the basis for the recommendations outlined in the 2017 Endocrine Society guidelines and has given rise to the so-called "gender affirmative" model of care for youth, which requires access to puberty blockers, hormones, and potentially surgery.
We agree with the concerns voiced by the recent publication, "Reconsidering Informed Consent for Trans-Identified Children, Adolescents, and Young Adults," that the Dutch studies have been misunderstood and misrepresented as providing evidence of the safety and efficacy of hormonal and surgical "gender-affirming" interventions for all youth. It is important that both the strengths and the weaknesses of these studies are thoroughly understood, as these two studies represent the best available evidence behind the practice of pediatric gender transition. You can read more about the strengths and limitations of the Dutch studies here.
The history of medicine has many examples in which the well-meaning pursuit of short-term relief of symptoms has led to devastating long-term results; for example the past use of thalidomide, lobotomies, and the recent opioid epidemic. The "gender affirmative" model commits young people to lifelong medical treatment with minimal attention to the etiology of their conditions, and the psychosocial factors contributing to gender dysphoria. This model dismisses the question of whether psychological therapy might help to relieve or resolve gender dysphoria and provides interventions without an adequate examination.
We are asking clinicians and researchers to halt this uncontrolled experimentation on youth and replace it with a supportive framework of research that generates useful evidence about the etiology of gender dysphoria and the benefits and harms of various interventions. We need to know:
Which factors contribute to the development of gender dysphoria?
Which are the most effective interventions in gender dysphoria?
What are the long-term outcomes of those interventions?
We propose that, in view of the current dearth of evidence, the application of the model to children, adolescents, and young adults is unjustified outside of research settings. Patients, families and clinicians cannot make informed healthcare decisions without knowing the likely benefits and harms of the various interventions.
SEGM promotes safe, compassionate, ethical and evidence-informed healthcare for children, adolescents, and young adults with gender dysphoria. You can donate via GoFundMe, by credit card, or by mailing us a check.
SEGM is a registered 501(c)(3) nonprofit organization. Contributions to SEGM are tax-deductible to the extent permitted by law. SEGM's tax identification number is 84-4520593.