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A recent publication examines and refutes several key assumptions that underlie an influential “pro-affirmation” paper published by the journal Nature.

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… gender dysphoria during or after puberty, challenge the notion that a … The Endocrine Society’s protocol (puberty blockers at the earliest stage of …

Over the last two years there has been a surge in research studies and systematic reviews reporting on the use of puberty blockers and cross-sex hormones as treatment for gender-distressed youth. This makes it difficult for the non-specialist to keep on top of the evidence. The psychiatrist...

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… for risks and benefits of puberty blockers and gender-affirming … reviews reporting on the use of puberty blockers and cross-sex hormones as …

Trans-identified youth present to clinicians as strongly desiring hormones and surgery. However, this conviction should not be confused with the capacity to carefully consider the consequences of gender transition, argues a recent article about informed consent in gender medicine,...

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… which entails the use of puberty blockers, cross-sex hormones, and … problems of youth with post-puberty onset of gender …

We welcome the American Academy of Pediatrics (AAP) decision to update treatment recommendations for gender dysphoric youth based on the results of a systematic...

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… policy for treating minors with puberty blockers, hormones and surgery … adverse effects of puberty blockers and …

The clinical lesson 'Youth with gender incongruence' by Dutch gender clinicians aims to describe Dutch adolescent gender care and its dilemma's. This commentary discusses five serious objections. First, the lesson fails to draw the implications from its acknowledgement of the paucity of evidence:...

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… of the paucity of evidence: puberty blockers and cross-sex hormones most … not acknowledge the dilemma that puberty blockers may impede, rather …

In 2020, the UK National Institute for Health and Care Excellence (NICE) undertook two systematic evidence reviews of the use of GnRH agonists (also known as "puberty blockers") and cross-sex hormones as treatments for...

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… of GnRH agonists (also known as "puberty blockers") and cross-sex hormones as …

Introduction: Medical care for transgender minors is understudied, largely because these forms of care are relatively recent. The primary objective of this work was to describe the cohort of transgender adolescents who initiated follow-up at the Strasbourg University Hospital before the age of 18,...

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… of 6% of adolescents received puberty blockers as monotherapy. The mean …

In ‘The Dutch Approach for Transgender Adolescents; Past, Present and Future Perspectives,’ clinicians and researchers from the Center of Expertise on Gender Dysphoria (CEGD) look back at three decades of CEGD research and conclude that, on the basis of these studies, they can now have ‘far more...

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… more confidence’ in providing puberty blockers, cross-sex hormones, and …

What has SEGM been up to this year? As we reach the end of 2024, we wanted to look back at this year's major developments in the field of youth gender medicine and look ahead to the challenges and opportunities 2025 presents.

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… of binding and tucking ), puberty blockers, and cross-sex hormones for … and long-term consequences of puberty blockers, hormones, and …

McNamara et al 2024's “An Evidence-Based Critique of the Cass Review” alleges that the Cass Review “repeatedly misuses data and violates its own evidentiary standards,” is “rife with misapplications of the scientific method,” and fails to evaluate the evidence "in a neutral and scientifically valid...

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… unethical," and advocated that puberty blockers, cross-sex hormones and … the Cass Review has done with puberty blockers for the treatment …

Search results

False Assumptions Behind Youth Gender Transitions

Pediatric gender affirming care is not evidence-based

Informed Consent for Gender-Affirmative Care

The American Academy of Pediatrics 2023 Policy Update

[Uncertainties around the current gender care: five problems with the clinical lesson 'Youth with gender incongruence']

Evidence review: gender-affirming hormones for children and adolescents with gender dysphoria

Retrospective Cohort Study of Transgender Adolescents at Strasbourg University Hospital

Three decades of ‘Dutch Protocol’ research has not produced reliable evidence

Looking Back on 2024 and Ahead to 2025

The Cass Review, the “Yale” Report, and the Importance of Keeping Special Interests at Bay