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In recent years, the use of gonadotropin-releasing hormone (GnRH) analogues in adolescents with gender dysphoria (GD) to suppress puberty has been adopted by an increasing number of gender clinics, generating controversial debate. This short essay provides an overview of the difficulties associated...

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… gender dysphoria (GD) to suppress puberty has been adopted by an … for and against the suspension of puberty. Further, it reviews the …

In this essay, we consider the clinical and ethical implications of puberty blockers for pediatric gender dysphoria through the lens of “the child’s right to an open future,” which refers to rights that children do not have the capacity to exercise as minors, but that must be protected, so they can...

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… and ethical implications of puberty blockers for pediatric gender … consent. We evaluate claims that puberty blockers are reversible, …

Aim Concerns have been raised regarding the impact of medications that interrupt puberty, given the magnitude and complexity of changes that occur in brain function and structure during this sensitive window of neurodevelopment. This review examines the literature on the impact of pubertal...

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… of medications that interrupt puberty, given the magnitude and … the neuropsychological impacts of puberty blockers are complex and often sex …

This Spotlight reviews the German Association of Scientific Medical Societies' 2024 draft guidelines for treating gender dysphoria and gender incongruence in childhood and adolescence and the role of evidence in the process of guideline development.

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… Report recommended withdrawing puberty blockers from commissioned … starting cross-sex hormones. Puberty blockers (PB) . PBs can be …

Unlike Europe, where national health service (NHS) agencies regulate the practice of medicine, the decentralized nature of the US healthcare system presents a distinct challenge when it comes to healthcare regulation. This is especially evident in the case of youth gender medicine, which relies...

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… original FDA approval for both puberty blockers and sex hormones dealt with … or restrictions on the use of puberty blockers and cross-sex …

The field of youth gender medicine remains in disarray, with increasing recognition of the harms of gender-affirming interventions clashing against continued reliance on unscientific “consensus” guidelines that bypass rigorous evidence-based standards. The German Guidelines acknowledge that most...

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… government to limit the use of puberty blockers and cross-sex hormones to … companies that manufacture puberty blockers. Further, there is …

The year 2020 has been pivotal in the field of gender medicine. Earlier this month, in a landmark decision, the UK High Court ruled that children under 16 are unlikely to be able to consent to the use of puberty blockers, which the Court deemed to be an experimental treatment. Rather than a “pause...

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… be able to consent to the use of puberty blockers, which the Court deemed to … button,” the court recognized puberty blockers as the first step … be able to consent to the use of puberty blockers, which the Court …

A major medical journal Ugeskrift for Læger, the Journal of the Danish Medical Association, confirmed that there has been a marked...

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… no longer get a prescription for puberty blockers, hormones or … underwent medical transition with puberty blockers or cross-sex …

In May 2025, the Utah Department of Health and Human Services released a 1,051-page evidence review of hormonal interventions for minors with gender dysphoria, accompanied by a recommendation report. This analysis,...

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… evidence,” which concluded that puberty blockers and cross-sex hormones are … of the off-label use of puberty blockers and cross-sex …

With some delay owing to hosting a major conference, we have now released Issue 3 of the SEGM Digest, our new initiative highlighting recent influential publications in pediatric gender medicine. Our Digests help busy professionals stay on top of important publications that relate to youth gender...

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… study evaluated the impact of puberty blockade (PB) on the … as being in later stages of puberty. The researchers found no … (67% female) treated with puberty blockers between 2020 and 2023. At …

Search results

Buying time or arresting development? The dilemma of administering hormone blockers in trans children and adolescents:

Puberty Suppression for Pediatric Gender Dysphoria and the Child’s Right to an Open Future

The impact of suppressing puberty on neuropsychological function: A review

The German Guidelines for Diagnosis and Treatment of Gender Incongruence and Gender Dysphoria of Childhood and Adolescence

Swedish Transgender Treatment Guidelines for Youth

2025 German Guidelines for Diagnosis and Treatment of Gender Incongruence and Gender Dysphoria of Childhood and Adolescence

2020 Gender Medicine Highlights

Denmark Joins the List of Countries That Have Sharply Restricted Youth Gender Transitions

The "Utah Review" of Hormonal Treatments for Gender-Dysphoric Minors: A Methodological Appraisal

Notable Publications in Gender Medicine, July–August 2025