Search results
The Signal—and the Noise—in the Field of Gender Medicine
January 31, 2022
Spotlight
Studies in the field of gender medicine are notoriously unreliable, plagued by small samples, lack of controls, confounding, and bias. This is true for even the “best” studies in the field, such as the “Dutch study...
Matched fragments:
… review of evidence of using puberty blockers (GnRH analogues) to treat … to find convincing evidence that puberty blockers are helpful (it … A recent systematic review of puberty blockers exemplifies …
Puberty blockers for gender dysphoria in youth: A systematic review and meta-analysis
January 24, 2025
Studies
Aim: Gender dysphoria (GD) refers to the psychological distress associated with the incongruence between one’s sex and one’s gender identity. To manage GD, individuals may delay the development of primary and secondary sex characteristics with the use of puberty blockers. In this systematic review...
Matched fragments:
… characteristics with the use of puberty blockers. In this systematic review, … the evidence about the effects of puberty blockers in individuals …
Puberty Blockers and Suicidality in Adolescents Suffering from Gender Dysphoria
October 1, 2020
Studies
According to Turban, King, Carswell, and Keuroghlian (2020), suicidal ideation is lower in transgender adults who as adolescents had been prescribed “puberty blockers”—gonadotropin-releasing hormone analogs (GnRHa). This finding was derived from a large nonrepresentative survey of transgender...
Matched fragments:
… adolescents had been prescribed “puberty blockers”—gonadotropin-releasing … respondents who reported taking puberty blockers. Turban et al. …
Use of puberty blockers for gender dysphoria: a momentous step in the dark
June 1, 2019
Studies
We write with three areas of concern about the increasing use of puberty-blocking medication for gender dysphoria (GD) referred to in your recent leading article.1
First, their use leaves a young person in developmental limbo without the benefit of pubertal hormones or secondary sexual...
Matched fragments:
… about the increasing use of puberty-blocking medication for … endocrinology clinics for puberty-blocking intervention … is that the use of puberty blockers may prevent some young …
Puberty Blockers for Children: Can They Consent?
June 27, 2022
Studies
Gender dysphoria is a persistent distress about one’s assigned gender. Referrals regarding gender dysphoria have recently greatly increased, often of a form that is rapid in onset. The sex ratio has changed, most now being natal females. Mental health issues pre-date the dysphoria in most. Puberty...
Matched fragments:
… pre-date the dysphoria in most. Puberty blockers are offered in clinics to help the child avoid puberty. Puberty blockers have known …
The 2023 Dutch Debate Over Youth Transitions
November 19, 2023
Spotlight
The Netherlands, like the rest of the Western world, has experienced an unprecedented increase in the number of youth seeking to undergo gender transition. Like the rest of the West, this sharp...
Matched fragments:
… the potential adverse effects of puberty blockers — a treatment that is … particularly the effects of puberty blockers on brain …
Puberty blockers do not alleviate negative thoughts in children with gender dysphoria, finds study
February 8, 2021
Studies
Puberty blockers used to treat children aged 12 to 15 who have severe and persistent gender dysphoria had no significant effect on their psychological function, thoughts of self-harm, or body image, a study has found.
However, as expected, the children experienced reduced growth in height and bone...
Matched fragments:
… Puberty blockers used to treat children aged … pause referrals of under 16s for puberty blockers. The appeal, expected to be …
The Tavistock’s Experiment with Puberty Blockers
July 1, 2019
Studies
In 1994 a 16-year-old girl who wished to be a boy, known to us as B, entered the Amsterdam
Gender Clinic. She was unique for having her sexual development halted at the age of 13,
after an adventurous paediatric endocrinologist gave her a Gonadotropin-Releasing Hormone
agonist (GnRHa). Originally...
Matched fragments:
… drugs are also used to delay puberty when it develops abnormally … to use the drug to stop normal puberty altogether, in order to … an experimental study of “puberty blockers”—the more friendly term for …
Toward a Standard of Medical Care: Why Medical Professionals Can Refuse to Prescribe Puberty Blockers
October 31, 2022
Studies
That a standard of medical care must outline services that benefit the patient is relatively uncontroversial. However, one must determine how the practices outlined in a medical standard of care should benefit the patient. I will argue that practices outlined in a standard of medical care must not...
Matched fragments:
… my thesis to the prescription of puberty blockers to children with gender …
Why Do the Bells Toll?: How to Understand and Address the Disputes Around Evidence in Support of the Use of Puberty Blockers for Young People with Gender Incongruence/Dysphoria
June 3, 2026
Studies
Disputes around puberty blockers and gender-affirming hormones for transgender and gender-diverse youth (TGDY) are often framed as disputes around evidence. Recent reviews, including NICE (2020) and the Cass Review (2024), have characterized the supporting evidence as “remarkably weak,” prompting...
Matched fragments:
… Disputes around puberty blockers and gender-affirming …