We are an international group of clinicians and researchers whose mission is to promote evidence-based approaches to the treatment of gender dysphoria in children, adolescents and young adults.
Cases of gender dysphoria appear to be rising sharply worldwide. The profile of patients has changed, such that adolescent females are now in a majority. Trauma, mental health difficulties and neuro-developmental diagnoses are very common associations. What's causing these changes is unknown, and the lack of robust evidence for current 'gender-affirmative' interventions concerns us.
The history of healthcare shows many well-intentioned and initially promising interventions that led to unintended harms, such as opioid overuse. To ensure the best outcomes for patients, clinicians and researchers must engage in a sober, independent, rigorous and high quality review of the science. We must be faithful to the core principle of medicine: first do no harm.