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Systematic Review of the Long-Term Effects of Transgender Hormone Therapy on Bone Markers and Bone Mineral Density and Their Potential Effects in Implant Therapy

June 1, 2019
Studies

SEGM Summary:

This systematic literature review aimed to determine the effects of long-term (follow-up >3 years) cross-sex hormone administration and non-hormonal pharmacological treatments on bone markers and bone mineral density (BMD) of adults with gender dysphoria. The review also...

Matched fragments:
… of several forms of testosterone and sex reassignment. …

Bone Mineral Density in Transgender Adolescents Treated With Puberty Suppression and Subsequent Gender-Affirming Hormones

December 1, 2023
Studies
OBJECTIVE: To assess BMD after long-term GAH treatment in transgender adults who used puberty suppression in adolescence. DESIGN, SETTING, AND PARTICIPANTS This single-center cohort study with follow-up duration of 15 years selected participants from a database containing all people visiting a...
Matched fragments:
… in transgender persons receiving testosterone, but bone health in …

NHS England Stops Prescribing Puberty Blockers and Updates its Cross-Sex Hormones Policy for Minors

March 29, 2024
Spotlight
In March 2024, NHS England (NHSE) updated its puberty blockers and cross-sex hormones policies for gender-dysphoric youth. The release of these policies coincides with the launch of the new service model, which will replace the Gender Identity Development Service (GIDS) at Tavistock as of April 1,...
Matched fragments:
… does not sufficiently suppress testosterone levels in natal males, …

The German Guidelines for Diagnosis and Treatment of Gender Incongruence and Gender Dysphoria of Childhood and Adolescence

May 20, 2024
Spotlight
This Spotlight reviews the German Association of Scientific Medical Societies' 2024 draft guidelines for treating gender dysphoria and gender incongruence in childhood and adolescence and the role of evidence in the process of guideline development.
Matched fragments:
… on ." Prior treatment with testosterone is not required, but if … that both the identity and post-testosterone breast size stabilize. …

Accurate transition regret and detransition rates are unknown

September 11, 2023
Spotlight

Like all medical interventions, “gender-affirming” interventions are associated with a range of physical and mental health outcomes—both positive and negative. Regret and detransition are examples of negative outcomes. Proponents of youth gender transition assert that rates of regret and...

Matched fragments:
… and suicidality following testosterone administration for … any physiological effects of testosterone—positive or …

The Detransition Rate Is Unknown

July 1, 2023
Studies

Like all medical interventions, “gender-affirming” interventions are associated with a range of physical and mental health outcomes—both positive and negative. Regret and detransition are examples of negative outcomes. Proponents of youth gender transition assert that rates of regret and...

Matched fragments:
… and suicidality following testosterone administration for … any physiological effects of testosterone—positive or …

2025 German Guidelines for Diagnosis and Treatment of Gender Incongruence and Gender Dysphoria of Childhood and Adolescence

March 26, 2025
Spotlight
The field of youth gender medicine remains in disarray, with increasing recognition of the harms of gender-affirming interventions clashing against continued reliance on unscientific “consensus” guidelines that bypass rigorous evidence-based standards. The German Guidelines acknowledge that most...
Matched fragments:
… who have not yet begun testosterone treatment.  Like the …

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