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Assisted reproductive technology outcomes in female-to-male transgender patients compared with cisgender patients: a new frontier in reproductive medicine

November 1, 2019
Studies
OBJECTIVE: To investigate assisted reproductive technology (ART) outcomes in a female-to-male transgender cohort and compare the results with those of a matched cisgender cohort. DESIGN: Matched retrospective cohort study. SETTING: In vitro fertilization clinic. PATIENT(S): Female-to-male...
Matched fragments:
… outcomes can be excellent even if testosterone therapy has already … can be achieved without stopping testosterone therapy. …

Changes in cardiometabolic risk factors in transmasculine individuals over 10 years of Gender-Affirming Hormone Therapy

May 22, 2026
Studies
Purpose to describe 10-year changes in health measures and cardiovascular risk among transmasculine adults on testosterone-based Gender-Affirming Hormone Therapy. Methods this is a single-centre, longitudinal cohort study of transmasculine adults who began Gender-Affirming Hormone Therapy and were...
Matched fragments:
… among transmasculine adults on testosterone-based Gender-Affirming … men. Conclusions Over 10 years, testosterone-based Gender-Affirming …

Epigenetic remodeling by sex hormone receptors and implications for gender affirming hormone therapy

May 8, 2025
Studies
Sex differences in immune system development and response to pathogens has been well documented, with females exhibiting more favorable outcomes for certain infections but a higher incidence of autoimmune disease compared to males. At least some of these sex differences are mediated by sex hormones...

Occurrence of Acute Cardiovascular Events in Transgender Individuals Receiving Hormone Therapy: Results From a Large Cohort Study

March 12, 2019
Studies

SEGM Summary

MtF and FtM patients taking cross-sex hormones were at much higher risk of serious cardiovascular illness than counterparts of the same biological sex in the general population. The authors advise that both physicians and gender dysphoric individuals seeking cross-sex hormone...

Case Study Considers Detransition

December 23, 2021
Spotlight
What happens when a young person's intensely experienced desire to undergo medical transition is granted, with minimal attention paid to the factors contributing to the development of gender dysphoria, and with no attempts to ameliorate the distress non-invasively first? A new publication, ...
Matched fragments:
… patient suspected that testosterone contributed to her …

What Went Wrong at the Tavistock Clinic for Trans Teenagers?

July 1, 2022
Spotlight

 

The Tavistock Centre in northwest LondonROMAS FOORD; GETTY IMAGES

For me it began with a graph. In 2017, I was shown a chart of children referred to GIDS, the Tavistock and Portman Trust’s Gender Identity Development Service clinic in northwest London. Overall case numbers had...

Matched fragments:
… decided whether to progress to testosterone at 16. Many parents, … significantly, in the US, where testosterone can be obtained from …

Brain Maturation, Cognition and Voice Pattern in a Gender Dysphoria Case under Pubertal Suppression

November 14, 2017
Studies

SEGM Summary:

This case study is the first report of neurological changes in an 11 year old male with gender dysphoria given gonadotropin releasing hormone analogs (GnRHa) to suppress puberty. The Wechsler tests were administered to assess global IQ (GIQ), comprehension, perceptual...

Matched fragments:
… be related to the reduced serum testosterone levels and/or to the … the follow-up seemed to reflect testosterone levels under …

Summary of Key Recommendations from the Swedish National Board of Health and Welfare (Socialstyrelsen/NBHW)

February 27, 2022
Spotlight
In February 2022, the Swedish National Board of Health and Welfare (NBHW) issued an update to its health care service guidelines for children and youth <18 with gender dysphoria / gender incongruence. This update contains 14 distinct “recommendations,” with justification for each, referencing a...
Matched fragments:
… for cross-sex hormones (estrogen, testosterone) Minimum age 16. …

Individuals Treated for Gender Dysphoria with Medical and/or Surgical Transition Who Subsequently Detransitioned: A Survey of 100 Detransitioners

November 1, 2021
Studies

To qualify as medically or surgically transitioned, participants needed to have had one or more of the following interventions for the purpose of transitioning: puberty blockers, cross-sex hormones, anti-androgens, or a surgical procedure, and then detransitioned by stopping the medications or...

Matched fragments:
… of their transition. Females took testosterone for an average 2 years, …

Swedish Transgender Treatment Guidelines for Youth

September 24, 2024
Spotlight

Unlike Europe, where national health service (NHS) agencies regulate the practice of medicine, the decentralized nature of the US healthcare system presents a distinct challenge when it comes to healthcare regulation. This is especially evident in the case of youth gender medicine, which relies...

Matched fragments:
… hormone treatment with testosterone or estrogen for …

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