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Transgender (trans) individuals identify with a gender that does not align with their biological sex. 13 For some, this leads to experiences of gender dysphoria and poor mental health. To address this, 14 some trans individuals, in consultation with health care providers, initiate gender affirming...

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… trans males) are treated with testosterone as monotherapy and 17 … with a combination of anti-testosterone and 18 estradiol. GAHT … of immune with the level of testosterone. In contrast, the …

In 2018 Andrea Davidson’s 12-year-old daughter, Meghan, announced she was “definitely a boy”. Ms Davidson says her child was never a tomboy but the family doctor congratulated her and asked what pronouns she had chosen, before writing a referral to the British Columbia Children’s Hospital (BCCH). “...

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… blockers and later undergo testosterone treatment and a double … student in Florida, started on testosterone aged 14 because of a … of this happening.” She came off testosterone, embraced her identity …

Objective. The primary objective of this cross-sectional study was to compare standard laboratory performance metrics of transgender athletes to cisgender athletes. Methods. 19 cisgender men (CM) (mean±SD, age: 37±9 years), 12 transgender men (TM) (age: 34±7 years), 23 transgender women (TW) (age...

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… in capillary blood and testosterone and oestradiol in serum … of athletes, TW had similar testosterone concentration (TW …

The World Health Organization's guideline development group leans heavily on prominent members of WPATH, including WPATH leadership involved in the suppression of unfavorable evidence related to cross-sex hormones.

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… (KQ5 below), and the effects of testosterone on on uterine, ovarian, … on gender-affirming therapy with testosterone, as measured by … men, what is the effect of testosterone therapy on uterine, …

This prospective but uncontrolled observational study investigated the effect of GnRH agonist therapy alone or with subsequent cross-sex hormone administration on markers of bone turnover, apparent bone density (BMAD) and bone density z-scores, with analysis of subjects started early (Tanner...

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… Biological females receiving testosterone showed improvement in … with estrogen. Females receiving testosterone showed near …

What happens when a young person's intensely experienced desire to undergo medical transition is granted, with minimal attention paid to the factors contributing to the development of gender dysphoria, and with no attempts to ameliorate the distress non-invasively first? This case study is an...

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… female after almost two years on testosterone. The author considers … The patient suspected that testosterone contributed to her …

BACKGROUND: Equations for estimated glomerular filtration rate (eGFR) based on serum creatinine include terms for sex/gender. For transgender and gender-diverse (TGD) youth, gender-affirming hormone (GAH) treatment may affect serum creatinine and in turn eGFR. METHODS: TGD youth were recruited for...

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… increased within 6 months of testosterone treatment (0.68 ± 0.10 … Participants DFAB treated with testosterone had serum creatinine …

The year 2020 has been pivotal in the field of gender medicine. Earlier this month, in a landmark decision, the UK High Court ruled that children under 16 are unlikely to be able to consent to the use of puberty blockers, which the Court deemed to be an experimental treatment. Rather than a “pause...

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… her with puberty blockers, testosterone, and subsequently …

The development of gender identity takes place under the influence of a complex interplay of social, psychological, and biological factors. Studies in individuals with disorders of sex development have suggested that exposure to androgens during fetal development and across the lifespan may...

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… severe hyperandrogenism (total testosterone 337 ng/dL, 11.7 nmol/L) … GnRH analog therapy reduced total testosterone to the cisgender female …

Experiments in male rodents demonstrate that sensitivity to the organizational effects of steroid hormones decreases across the pubertal window, with earlier androgen exposure leading to greater masculinization of the brain and behavior. Similarly, some research suggests the timing of peripubertal...

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… men, controlling for current testosterone levels in Study 2. In … was unrelated to salivary testosterone in Study 2. In Study 4, …

Search results

Editorial: Gender affirming hormone therapy and its immunological implications

An English Ruling on Transgender Teens Could Have Global Repercussions

Strength, power and aerobic capacity of transgender athletes: a cross-sectional study

WPATH Influence Undermines WHO’s Transgender Guidelines

Bone Development in Transgender Adolescents Treated With GnRH Analogues and Subsequent Gender-Affirming Hormones

Gender detransition: a case study

The effect of gender-affirming hormone treatment on serum creatinine in transgender and gender-diverse youth: implications for estimating GFR

2020 Gender Medicine Highlights

Severe Hyperandrogenism Secondary to Polycystic Ovarian Syndrome in a Gender-diverse Adolescent

Timing of peripubertal steroid exposure predicts visuospatial cognition in men: Evidence from three samples