Search results
Physical changes, laboratory parameters, and bone mineral density during testosterone treatment in adolescents with gender dysphoria
September 1, 2019
Studies
This retrospective uncontrolled study investigated the metabolic and bone effects of testosterone administration on 62 gender dysphoric female subjects after GnRH agonist mediated pubertal blockade. Following 6 and 12 months of testosterone administration, BMAD z-scores remained below those...
Matched fragments:
… hormone agonists (GnRHa) and testosterone in transgender males. … on the safety and efficacy of testosterone is based on studies in … the efficacy and safety of testosterone treatment in …
Effects of testosterone treatment on hypothalamic neuroplasticity in female-to-male transgender individuals
January 1, 2018
Studies
SEGM Summary:
This study aimed to determine the influence of testosterone administration on the brains of 25 natal females with gender dysphoria. Measurements were made using whole-brain diffusion-weighted image (DWI) scans at baseline, 4 weeks, and 4 months post treatment. The subjects...
Matched fragments:
… a potential influence of testosterone replacement therapy on … and bilaterally after 4 months of testosterone treatment. Moreover, … androgen index and bioavailable testosterone were significantly …
Cardiovascular mortality associated with testosterone therapy in cisgender women and transgender men: a systematic review
February 11, 2026
Studies
Background
Testosterone therapy is increasingly prescribed in cisgender women for sexual and metabolic indications and constitutes the cornerstone of gender-affirming hormone therapy in transgender men. However, the nature and certainty of cardiovascular safety evidence supporting testosterone use...
Matched fragments:
… Background Testosterone therapy is increasingly … safety evidence supporting testosterone use differ across … mortality associated with testosterone therapy in cisgender …
Testosterone use and sexual function among transgender men and gender diverse people assigned female at birth
December 1, 2023
Studies
BACKGROUND: Testosterone use among transgender people likely impacts their experience of sexual function and vulvovaginal pain via several complex pathways. Testosterone use is associated with decreased estrogen in the vagina and atrophic vaginal tissue, which may be associated with decreased...
Matched fragments:
… BACKGROUND: Testosterone use among transgender … via several complex pathways. Testosterone use is associated with … gender affirmation through testosterone use may be associated …
Testosterone reduces functional connectivity during the ‘Reading the Mind in the Eyes’ Test
June 1, 2016
Studies
SEGM Summary:
Typically, females have greater ability than males to accurately interpret motives from the body language and physical expressions of others. This study sought to determine the effect of testosterone on cognitive empathic ability.
In a randomized cross-over, placebo-...
Matched fragments:
… interaction. The steroid hormone testosterone is thought to play a … that a single administration of testosterone in women impairs … ring finger, a proxy for fetal testosterone. Research in typical …
Testosterone therapy and the risk of atrial fibrillation, venous thromboembolism and cardiovascular events in cis men with hypogonadism and trans men
September 1, 2025
Studies
While the cardiovascular safety of testosterone therapy in men remains controversial, limited data exist for trans men treated with testosterone. We assessed cardiovascular events, mortality, and suicide attempts under testosterone therapy in both cis men with hypogonadism and trans men....
Matched fragments:
… While the cardiovascular safety of testosterone therapy in men remains … exist for trans men treated with testosterone. We assessed … and suicide attempts under testosterone therapy in both cis men …
Plasma testosterone concentration is correlated with circulating immune cell abundance in transgender young people on gender-affirming hormone treatment
July 10, 2025
Studies
Sex hormones, such as oestrogen and testosterone, display significant immune modulatory properties. This is highly relevant for transgender (trans) people who undergo gender-affirming hormone (GAH) treatment. However, only a limited number of studies have evaluated the immunological impact of GAH...
Matched fragments:
… hormones, such as oestrogen and testosterone, display significant … (birth-registered females taking testosterone-based GAH) and trans … concentrations of oestradiol and testosterone using multiple …
How do elevated levels of testosterone affect the function of the human fallopian tube and fertility?—New insights
January 1, 2020
Studies
Excess testosterone levels affect up to 20% of the female population worldwide and are a key component in the pathogenesis of polycystic ovary syndrome. However, little is known about how excess testosterone affects the function of the human fallopian tube—the site of gamete transport,...
Matched fragments:
… Excess testosterone levels affect up to 20% … little is known about how excess testosterone affects the function of … by long‐term exposure to male testosterone levels. For this …
Cerebral Venous Sinus Thrombosis Associated With Testosterone Use as Gender-Affirming Hormone Therapy in a Transgender Patient: Case Report and Literature Review
January 1, 2026
Studies
Transgender and gender-expansive (TG) people frequently experience gender dysphoria, which is associated with negative mental health. The use of gender-affirming hormone therapy (GAHT) is an important strategy in the management of this population. However, this therapy, especially with the use of...
Matched fragments:
… especially with the use of testosterone, is associated with a … dysphoria, started receiving testosterone undecanoate as … thrombotic event associated with testosterone as gender-affirming …
The ovaries of transgender men indicate effects of high dose testosterone on the primordial and early growing follicle pool
March 31, 2023
Studies
Androgens are essential in normal ovarian function and follicle health, but hyperandrogenism, as seen in polycystic ovary syndrome, is associated with disordered follicle development. There are few data on the effect of long-term exposure to high levels of testosterone as found in transgender men...
Matched fragments:
… exposure to high levels of testosterone as found in transgender … we investigate the effect of testosterone on the development, … oophorectomy taking pre-operative testosterone therapy. This was …