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Looking Back on 2024 and Ahead to 2025
December 30, 2024
Spotlight
What has SEGM been up to this year?
As we reach the end of 2024, we wanted to look back at this year's major developments in the field of youth gender medicine and look ahead to the challenges and opportunities 2025 presents.
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… of binding and tucking ), puberty blockers, and cross-sex hormones for … and long-term consequences of puberty blockers, hormones, and …
The Cass Review, the “Yale” Report, and the Importance of Keeping Special Interests at Bay
October 22, 2024
Spotlight
McNamara et al 2024's “An Evidence-Based Critique of the Cass Review” alleges that the Cass Review “repeatedly misuses data and violates its own evidentiary standards,” is “rife with misapplications of the scientific method,” and fails to evaluate the evidence "in a neutral and scientifically valid...
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… unethical," and advocated that puberty blockers, cross-sex hormones and … the Cass Review has done with puberty blockers for the treatment …
The Evidence to Support Medicalised Gender Transitions in Adolescents is Worryingly Weak
April 14, 2023
Spotlight
Prisha Mosley was 17 when she was first given testosterone in a clinic in North Carolina, after she had declared to her parents that she was a boy. She had struggled through her teen years with anorexia and depression after a sexual assault. Luka Hein had both breasts removed as a 16-year-old in...
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… She had been on testosterone and puberty-blocking drugs since 13, … some of them a combination of puberty-blocking drugs, opposite-sex … teenagers were prescribed puberty-blockers or cross- sex hormones in …
Critical Appraisal of “Long-Term Regret and Satisfaction With Decision Following Gender-Affirming Mastectomy”
August 13, 2023
Spotlight
Recent research published in JAMA Surgery evaluated satisfaction and regret among individuals who had undergone...
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… that claimed that access to puberty blockers reduce the risk of suicide … that individuals reporting use of puberty blockers use had twice as …
The Cass Review and Gender-Related Care for Young People in Canada: A Commentary on the Canadian Paediatric Society Position Statement on Transgender and Gender-Diverse Youth
November 21, 2025
Studies
In this peer-reviewed publication Chan Kulatunga Moruzi and colleagues raise substantial concerns about the 2023 Canadian Paediatric Society Position Statement (CPS-PS), “An...
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… physicians need to know about puberty blockers (PBs) and gender-affirming … benefits and understates risks of puberty blockers and hormone therapy. …
Gender-affirming care for transgender and gender-diverse youth in Oregon: trends over time
April 9, 2026
Studies
Background and Aims
Despite increasing attention, population-level evidence on medical gender-affirming care (GAC) used among transgender and gender-diverse (TGD) adolescents remains limited, and little is known about use in supportive policy environments. To describe population-level patterns and...
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… dysphoria and assessed receipt of puberty blockers and gender-affirming … received medical GAC (8% puberty blockers; 20% hormone …
"Gender-affirming" Hormones and Surgeries for Gender-Dysphoric US Youth
May 28, 2021
Spotlight
Following the 60 Minutes episode earlier this week, which highlighted the controversies surrounding medical interventions for gender dysphoric youth, SEGM has been receiving an increasing number of inquiries about the state of gender care for youth in the United States. One question in particular...
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… appeared for the first time after puberty were considered at a high … Dutch protocol (the sequence of puberty blockade, cross-sex-hormones … The provision of puberty blockers, cross-sex-hormones, or …
Letter to the Editor: “Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons: An Endocrine Society Clinical Practice Guideline”
March 1, 2019
Studies
Childhood gender dysphoria (GD) is not an endocrine condition, but it becomes one through iatrogenic puberty blockade (PB) and high-dose cross-sex (HDCS) hormones. The consequences of this gender-affirmative therapy (GAT) are not trivial and include potential sterility, sexual dysfunction,...
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… it becomes one through iatrogenic puberty blockade (PB) and high-dose …
In Support of Research Into Rapid-Onset Gender Dysphoria
January 1, 2020
Studies
A group of clinicians extensively working with gender dysphoric youth confirm the emergence of a phenomenon that as been described as "adolescent-onset gender dysphoria," "rapid onset gender dysphoria," as well as several other terms.
They note, "while there is an ongoing debate about how...
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… to or during the early stages of puberty (certainly nothing of …
Accurate transition regret and detransition rates are unknown
September 11, 2023
Spotlight
Like all medical interventions, “gender-affirming” interventions are associated with a range of physical and mental health outcomes—both positive and negative. Regret and detransition are examples of negative outcomes. Proponents of youth gender transition assert that rates of regret and...
Matched fragments:
… a mix of interventions (including puberty blockers, hormones, and/or … 17,000 children aged 6–17 started puberty blockers or hormones from …