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Gender-affirming care for transgender and gender-diverse youth in Oregon: trends over time

April 9, 2026
Studies
Background and Aims Despite increasing attention, population-level evidence on medical gender-affirming care (GAC) used among transgender and gender-diverse (TGD) adolescents remains limited, and little is known about use in supportive policy environments. To describe population-level patterns and...
Matched fragments:
… dysphoria and assessed receipt of puberty blockers and gender-affirming … received medical GAC (8% puberty blockers; 20% hormone …

"Gender-affirming" Hormones and Surgeries for Gender-Dysphoric US Youth

May 28, 2021
Spotlight
Following the 60 Minutes episode earlier this week, which highlighted the controversies surrounding medical interventions for gender dysphoric youth, SEGM has been receiving an increasing number of inquiries about the state of gender care for youth in the United States. One question in particular...
Matched fragments:
… appeared for the first time after puberty were considered at a high … Dutch protocol (the sequence of puberty blockade, cross-sex-hormones … The provision of puberty blockers, cross-sex-hormones, or …

YOUTH GENDER DISTRESS

Conferences
SEGM 2025 Berlin Conference: Welcoming Address by Dr. Klaus Reinhardt

Our Berlin conference brought together researchers, clinicians, and academics from more than 20 countries, representing a range of specialties and viewpoints. With over 40 speakers, the event facilitated thoughtful discussion and debate on how to understand and support gender-dysphoric young people.

The Youth Gender Distress conference has been endorsed by the International Association of Child and Adolescent Psychiatry and Allied Professions (IACAPAP).
Matched fragments:
… Evidence Reviews for Puberty Blockers, Hormones, and Surgeries … to discover the experiment with puberty blockers conducted by the … gender-dysphoric youth with puberty blockers and cross-sex …

Letter to the Editor: “Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons: An Endocrine Society Clinical Practice Guideline”

March 1, 2019
Studies
Childhood gender dysphoria (GD) is not an endocrine condition, but it becomes one through iatrogenic puberty blockade (PB) and high-dose cross-sex (HDCS) hormones. The consequences of this gender-affirmative therapy (GAT) are not trivial and include potential sterility, sexual dysfunction,...
Matched fragments:
… it becomes one through iatrogenic puberty blockade (PB) and high-dose …

In Support of Research Into Rapid-Onset Gender Dysphoria

January 1, 2020
Studies

A group of clinicians extensively working with gender dysphoric youth confirm the emergence of a phenomenon that as been described as "adolescent-onset gender dysphoria," "rapid onset gender dysphoria," as well as several other terms.

They note, "while there is an ongoing debate about how...

Matched fragments:
… to or during the early stages of puberty (certainly nothing of …

Accurate transition regret and detransition rates are unknown

September 11, 2023
Spotlight

Like all medical interventions, “gender-affirming” interventions are associated with a range of physical and mental health outcomes—both positive and negative. Regret and detransition are examples of negative outcomes. Proponents of youth gender transition assert that rates of regret and...

Matched fragments:
… a mix of interventions (including puberty blockers, hormones, and/or … 17,000 children aged 6–17 started puberty blockers or hormones from …

The Detransition Rate Is Unknown

July 1, 2023
Studies

Like all medical interventions, “gender-affirming” interventions are associated with a range of physical and mental health outcomes—both positive and negative. Regret and detransition are examples of negative outcomes. Proponents of youth gender transition assert that rates of regret and...

Matched fragments:
… is medical intervention (i.e., puberty blockers, hormones, and/or … a mix of interventions (including puberty blockers, hormones, and/or …

Gender Identity Disorders in Childhood and Adolescence

November 1, 2008
Studies

SEGM Summary:

This is a review of gender identity disorders in childhood and adolescence and the question of early hormone treatment from a German clinic. Gender atypical childhood behavior often leads to homosexual orientation in adulthood, including in children with GID. Only a minority...

Matched fragments:
… of LHRH analogues that prevent puberty. … have been arrested had they taken puberty blockers. Puberty blocking treatment …

Fertility preservation: is there a model for gender-dysphoric youth?

April 11, 2025
Studies

Endocrinologist Michael Laidlaw, along with obstetrician and gynecologist Angela Thompson and Jennifer Lahl (R.N., M.A., and President of the Center for Bioethics and Culture) examine the current understandings and ethical issues surrounding fertility preservation (FP) for children and...

Matched fragments:
… that FP methods used during early puberty (which can occur as young as … advocated by the Dutch Protocol — puberty blockers administered at the …

Transgender Identity and Suicide Attempts and Mortality in Denmark

July 9, 2023
Spotlight

A recently published study from Denmark compared the rate of suicide attempts, suicide-related deaths, non-suicide-related deaths, and all-cause mortality between non-transgender and transgender-identifying individuals...

Matched fragments:
… model, which recommends starting puberty blockers at the earliest stage of puberty, before proceeding to …

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SEGM is committed to safeguarding scientific integrity through open discourse and collaboration. Researchers and clinicians worldwide must be free to pursue scientific inquiry without censorship or intimidation.

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