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Introducing the SEGM Digest

This issue is the first installment of the SEGM Digest, a new series that will highlight recent influential publications in pediatric gender medicine. When we first launched our Spotlight series in 2019 the field was producing relatively few publications. As of 2025,...

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… reviews reporting on the use of puberty blockers and cross-sex hormones as … harm their future fertility. When puberty blockers are provided at the …

The editorial was written in response to several US bills that aim to limit the use of hormones and surgery in minors. The editorial asserted that hormonal and surgical interventions for gender-dysphoric youth are proven treatments; that puberty blockers are fully reversible and prevent...

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… youth are proven treatments; that puberty blockers are fully reversible and … to the Editor (LTE). The LTE “Puberty Blockers for Gender …

When Jane Clark’s 15-year-old daughter told her that she thought she might be gay, Dr Clark, a paediatrician who calls herself a “typical west-coast liberal”, said, “ok, great.” When the child a few months later said she thought she was non-binary, “I was, like, I don’t know what that means, but ok...

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… and medical transition, including puberty blockers, cross-sex hormones and … that studies on the impact of puberty blockers are “either of …

Consistent with the principle, “First, do no harm,” psychologist David Schwartz, Ph.D. exhorts clinicians to treat children and adolescents with gender dysphoria (GD) using psychotherapy rather than pharmacological and surgical interventions. He asserts, “in the treatment of children and...

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… genetic make-up of the child, or puberty blockers, are all clinical practices … we are instigating.” Although puberty blockers are promoted as “a …

SEGM Summary:

This retrospective study looked at bone mineral density (BMD) in 34 young gender dysphoric adults at the average age of 22, who had been given gonadotropin releasing hormone analog (GnRHa) to suppress or delay puberty for 1.3 - 1.5 years, followed by cross-sex hormones for...

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… (DSM IV-TR) who started SR in puberty and had undergone … (GnRHa) to suppress or delay puberty for 1.3 - 1.5 years, … young adults treated with puberty blockers during mid-adolescence had …

In 2020, the UK National Institute for Health and Care Excellence (NICE) undertook two systematic evidence reviews of the use of GnRH agonists (also known as "puberty blockers") and cross-sex hormones as treatments for...

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… of GnRH agonists (also known as "puberty blockers") and cross-sex hormones as …

Gonadotropin-releasing hormone agonists are used to treat central precocious puberty and are increasingly prescribed in gender-affirming care. Despite well-established reproductive effects, their broader physiological effects during puberty remain poorly understood. Male and female Wistar rats...

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… used to treat central precocious puberty and are increasingly … physiological effects during puberty remain poorly understood. … This suggests that puberty blockers exert broader …

The following publication appeared in the Economist online on December 2, 2024. The article has been reproduced below fully, with permission.

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… Senate Bill 1 (SB1), which bans puberty blockers, cross-sex hormones and … identify as transgender and want puberty blockers or hormones (the …

The National Academy of Medicine in France has issued a press release in which it cautions medical practitioners that the growing cases of transgender identity in young people are often socially-mediated and that great caution in treatment is needed. The Academy draws attention to...

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… Stockholm to prohibit the use of puberty blockers. If France allows the use of puberty blockers or cross-sex …

Background

In February 2022, the Swedish National Board of Health and Welfare (NBHW) issued an update to its health care service guidelines...

Search results

Notable Publications in Gender Medicine, April-May 2025

A flawed agenda for trans youth

Questioning America’s Approach to Transgender Health Care

Clinical and Ethical Considerations in the Treatment of Gender Dysphoric Children and Adolescents: When Doing Less Is Helping More

Bone Mass in Young Adulthood Following Gonadotropin-Releasing Hormone Analog Treatment and Cross-Sex Hormone Treatment in Adolescents With Gender Dysphoria

Evidence review: gonadotrophin releasing hormone analogues for children and adolescents with gender dysphoria

Pubertal Triptorelin Exposure Alters Hypothalamic Reproductive–Metabolic Integration in a Sex-Specific Manner

A big transgender-rights case heads to America’s Supreme Court

National Academy of Medicine in France Advises Caution in Pediatric Gender Transition

Care of children and adolescents with gender dysphoria: summary