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That a standard of medical care must outline services that benefit the patient is relatively uncontroversial. However, one must determine how the practices outlined in a medical standard of care should benefit the patient. I will argue that practices outlined in a standard of medical care must not...

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… my thesis to the prescription of puberty blockers to children with gender …

Disputes around puberty blockers and gender-affirming hormones for transgender and gender-diverse youth (TGDY) are often framed as disputes around evidence. Recent reviews, including NICE (2020) and the Cass Review (2024), have characterized the supporting evidence as “remarkably weak,” prompting...

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… Disputes around puberty blockers and gender-affirming …

Objective: The suppression of physiological puberty using puberty-blocking pharmacological agents (PB) and prescribing cross-sex hormones (CSH) to minors with gender dysphoria (GD) is a current matter of discussion, and in some cases, PB and CSH are used in clinical practice for this particular...

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… The suppression of physiological puberty using puberty-blocking pharmacological …

This article considers the claim that gender diverse minors and their families should not be able to consent to hormonal treatment for gender dysphoria. The claim refers particularly to hormonal treatment with so-called ‘blockers’, analogues that suspend temporarily pubertal development. We discuss...

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… treatment with so-called ‘blockers’, analogues that suspend …

The Editorial in The Lancet Child & Adolescent Health stated that trans youth “have the same right to health and wellbeing as all humans”. However what constitutes good health care for this population is far from clear based on the available evidence.

The medical transition of children and adolescents with gender dysphoria remains highly debated and there is significant divergence in policy internationally.1-7 Mills and colleagues' review the interventions that comprise the “gender-affirmative” care pathway, an approach currently promoted by...

We continue our series in this month’s SEGM Digest, which highlights a shift in the youth gender transition debate, with growing focus on ethical and regulatory concerns. We review key bioethics publications and court rulings likely to shape future regulation which came out in June 2025. Despite...

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… and adolescents prescribed puberty blockers (PB) for gender dysphoria … in Transgender Adults Following Puberty Suppression Treatment During …

The Cass Review of England’s gender services for children and young people, initiated four years ago, culminated earlier this week in the publication of the final 388-page report. The report was...

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… protocol for youth comprising of puberty blockers, cross-sex hormones, and … Regarding Social Transition, Puberty Blockers, Cross-Sex … England’s current policies for Puberty Blockers and Cross-Sex …

This study assessed long-term sexual satisfaction and dysfunction among 70 individuals who began puberty suppression (PS) at the Amsterdam gender clinic between 1998 and 2011, selected from an original cohort of 145. All participants later initiated cross-sex hormones, and many underwent genital...

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… following treatment with puberty suppression (PS) have not … do not undergo (full) endogenous puberty. However, attention for … among 70 individuals who began puberty suppression (PS) at the …

SEGM Summary:

Background: Dutch clinicians hypothesized that transgender adults would have better psychological outcomes if they received earlier intervention. They proposed an intervention model consisting of puberty blockers, cross-sex hormones, and genital and non-genital surgeries to...

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… Introduction. Puberty suppression by means of … gender dysphoria before and after puberty suppression in gender … eligible candidates who received puberty suppression between 2000 and …

Search results

Toward a Standard of Medical Care: Why Medical Professionals Can Refuse to Prescribe Puberty Blockers

Why Do the Bells Toll?: How to Understand and Address the Disputes Around Evidence in Support of the Use of Puberty Blockers for Young People with Gender Incongruence/Dysphoria

Beyond NICE: Updated systematic review on the current evidence for using puberty blockers and cross-sex hormones in minors with gender dysphoria: Electronic supplementary online materials I: adapted abbreviated English version

Gender dysphoria in adolescents: can adolescents or parents give valid consent to puberty blockers?

Puberty blockers for gender dysphoria: the science is far from settled

Puberty blockers for gender dysphoric youth: A lack of sound science

Notable Publications in Gender Medicine, June 2025

The Final Cass Review and the NHS England Response

Sexual satisfaction and dysfunction in transgender adults following puberty suppression treatment during adolescence

Puberty Suppression in Adolescents With Gender Identity Disorder: A Prospective Follow‐Up Study